Ortho-phthalaldehyde (OPA) has been around since the early 1990s as a safer disinfectant active for treating instruments and devices, in comparison to glutaraldehyde. OPA is found to be very compatible with most materials used to manufacturer medical instruments. Contrary to common belief, OPA is one of the members of the aldehyde family that does not have the characteristic pungent odor associated with formaldehyde etc. OPA is known to maintain its biocidal activity in a wide range of pH, while being compatible with various materials and equipment.
OPA causes malfunction of the bacterial cell membrane by attaching to protein residues and receptors and which also increases the permeability to OPA allowing the chemical to enter the cell. Once in the cell, OPA interacts with enzymes and RNA and thus causes failure of cellular functions, which leads to bacterial cell death. OPA at various use dilution is known to be a bactericide, virucide, fungicide, and tuberculocide and is widely used as a high level disinfectant for reprocessing semi-critical medical devices (e.g. items that will come in contact with mucous membranes or non-intact skin). Sporicidal activity OPA is very limited and dependent on the pH and the contact time is considered to be too long to be useful for reprocessing activities.
At use dilution of 0.5% to 5%, OPA does not impose any flammability or reactivity hazards. There has been reports of residual OPA exposure from endoscopes and trans-esophageal probes to patients, where it has caused exacerbation of asthma and bronchitis, and general sensitization. At use dilution, OPA is found to be a sensitizer to eye, skin and respiratory organs, however, current scientific evidence has not found OPA to be mutagenic or carcinogenic.
DISINFECTANTS AND PRODUCTION PROCESS
MANUFACTURING PROCESS OF ORTHO PHTHALALDEHYDE DISINFECTANTS is not very complicated. For the production, there is need usable and tried a formulation, raw materials and mixing tank. For raw materials to be used, quantities to be used and ingredients usage rankings, you should look into this formulation. Therefore, formulation and productıon methods of ortho phtalaldehyde disinfectant solutions are important. If you have not a good formulation, you cannot make healthy and efficient production of any disinfectant products and derivatives.
DISINFECTANT PRODUCTS FORMULATIONS ENCYCLOPEDIA
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